Pyridines and derivatives
- (4)
- (1)
- (5)
- (5)
- (597)
- (22)
- (2,186)
- (22)
- (2)
- (5)
- (5)
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- (181)
- (1)
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- (51)
- (2)
- (303)
- (87)
- (245)
- (6)
- (4)
- (2)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (5)
- (1)
- (12)
- (4)
- (8)
- (7)
- (12)
- (60)
- (875)
- (6)
- (56)
- (66)
- (58)
- (19)
- (357)
- (2)
- (4)
- (2)
- (1)
- (1)
- (5)
- (303)
- (1)
- (1,713)
- (2)
- (29)
- (7)
- (1)
- (92)
- (4)
- (15)
- (86)
- (128)
- (55)
- (60)
- (2)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (5)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (3)
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- (1)
- (1)
- (1)
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- (1)
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- (9)
- (4)
- (1)
- (2)
- (4)
- (2)
- (1)
- (6)
- (17)
- (23)
- (1)
- (1)
- (63)
- (21)
- (1)
- (1)
- (29)
- (50)
- (7)
- (2)
- (1)
- (5)
- (6)
- (12)
- (1)
- (1)
- (1)
- (1)
- (18)
- (1)
- (14)
- (4)
- (1)
- (11)
- (5)
- (1)
- (10)
- (17)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (9)
- (7)
- (1)
- (2)
- (1)
- (4)
- (6)
- (2)
- (1)
- (1)
- (1)
- (4)
- (4)
- (1)
- (1)
- (5)
- (15)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (12)
- (1)
- (2)
- (1)
- (2)
- (4)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (15)
- (18)
- (4)
- (2)
- (2)
- (5)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (7)
- (5)
- (9)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (16)
- (7)
- (5)
- (1)
- (1)
- (3)
- (5)
- (10)
- (2)
- (1)
- (6)
- (6)
- (7)
- (12)
- (1)
- (1)
- (39)
- (1)
- (12)
- (11)
- (4)
- (2)
- (2)
- (15)
- (15)
- (1)
- (1)
- (1)
- (2)
- (9)
- (3)
- (2)
- (1)
- (1)
- (1)
- (4)
- (6)
- (3)
- (3)
- (1)
- (4)
- (1)
- (1)
- (1)
- (3)
- (3)
- (1)
- (6)
- (5)
- (2)
- (1)
- (19)
- (9)
- (1)
- (2)
- (1)
- (1)
- (1)
- (22)
- (24)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (22)
- (16)
- (6)
- (2)
- (1)
- (1)
- (3)
- (7)
- (1)
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- (3)
- (1)
- (1)
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- (1)
- (8)
- (17)
- (3)
- (1)
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- (1)
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- (1)
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- (1)
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- (3)
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- (2)
- (1)
- (1)
- (1)
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- (3)
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- (3)
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- (1)
- (1)
- (1)
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- (1)
- (1)
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- (1)
- (1)
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- (5)
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- (1)
- (4)
- (12)
- (49)
- (1)
- (4)
- (2)
- (3)
- (1)
- (2)
- (1)
- (1)
- (7)
- (10)
- (22)
- (30)
- (1)
- (1)
- (1)
- (3)
- (2)
- (2)
- (4)
- (11)
- (5)
- (1)
- (1)
- (55)
- (6)
- (1)
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- (1)
- (1)
- (1)
- (1)
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- (1)
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- (35)
- (3)
- (4)
- (4)
- (3)
- (1)
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- (19)
- (1)
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- (1)
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- (11)
- (18)
- (1)
- (2)
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- (8)
- (6)
- (2)
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- (1)
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- (2)
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- (2)
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- (1)
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- (2)
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- (2)
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- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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- (2)
- (1)
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- (1)
- (1)
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- (4)
- (1)
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- (1)
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- (2)
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- (4)
- (1,561)
- (2)
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- (12)
- (9)
- (1)
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- (3)
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- (3)
- (2)
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- (4)
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- (1)
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- (3)
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- (11)
- (13)
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- (2)
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- (1)
- (2)
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- (5)
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- (2)
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- (2)
- (3)
- (2)
- (237)
- (3)
- (2)
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- (5)
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- (3)
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Filtered Search Results
Bioss Anti-PAR4 Antibody
Anti-PAR4 Antibody
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Medchemexpress LLC Pictilisib (dimethanesulfonate) | 957054-33-0 | 99.7% | 705.85 | 1 ML
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, showing modest selectivity against p110β and p110γ. It effectively reduces tumor cell viability in breast cancer cell lines, inhibits Akt phosphorylation, and demonstrates strong antitumor activity in ZD1839-resistant non-small cell lung cancer lines. This compound also induces cell growth inhibition, G0-G1 arrest, and apoptosis in combination with U0126.
- Potent PI3Kα/δ inhibitor (IC50: 3 nM)
- Modest selectivity against p110β (11-fold) and p110γ (25-fold)
- Reduces tumor cell viability in breast cancer cell lines
- Inhibits Akt phosphorylation
- Effective against ZD1839-resistant non-small cell lung cancer
- Induces cell growth inhibition, G0-G1 arrest, and apoptosis in combination with U0126
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC BGC-20-1531 free base | 736183-35-0 | 98.1% | 492.54 | 1 ML
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist with a pKB of 7.6. It has potential for migraine headache research, competitively antagonizing PGE2-induced vasodilatation in human middle cerebral and meningeal arteries, while showing no effect on responses induced by PGE2 in coronary, pulmonary or renal arteries. In vivo, it causes a dose-dependent antagonism of PGE2-induced increase in canine carotid blood flow.
- Potent and selective prostanoid EP4 receptor antagonist.
- Potential for migraine headache research.
- Competitively antagonizes PGE2-induced vasodilatation of human middle cerebral and meningeal arteries.
- Shows no effect on responses induced by PGE2 on coronary, pulmonary or renal arteries.
- Causes a dose-dependent antagonism of PGE2-induced increase in canine carotid blood flow in vivo.
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Medchemexpress LLC Ethiprole | 181587-01-9 | ≥98.0% | 10MM 1ML
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Ethiprole | 181587-01-9 | ≥98.0% | 10MM 1ML
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Apexbio Technology LLC NVP-BHG712 940310-85-0 50mg
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NVP-BHG712 (CAS 940310-85-0) is a selective small molecule inhibitor targeting the EphB4 receptor tyrosine kinase exhibiting an ED50 of 5 nM for EphB4 and reduced activity toward VEGFR2 (ED50 4200 nM) NVP-BHG712 demonstrates potent inhibition of EphB4 phosphorylation in cellular assays and shows weaker effects on EphB2 EphA2 EphB3 and EphA3 In cell-based models NVP-BHG712 suppresses proliferation and viability of synovial sarcoma cells and increases paclitaxel sensitivity in HEK293/ABCC10 cells In vivo it inhibits VEGF-induced angiogenesis and reduces tumor growth and metastasis in murine xenograft models This compound is a valuable probe for studying EphB4-mediated signaling in cancer and angiogenesis research
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Apexbio Technology LLC MLN2238(Synonyms: Ixazomib, MLN-2238, Ninlaro, MLN9708, Ixazomib citrate), 50mg, CAS: 1072833-77-2.
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MLN2238 (CAS number 1072833-77-2) is a dipeptidyl boronic acid derivative designed as a reversible inhibitor of the 5 subunit (chymotrypsin-like activity) of the 20S proteasome with reported IC50 and Ki values of 3 4 nM and 0 93 nM respectively At higher concentrations MLN2238 also targets the proteasome s 1 (caspase-like) and 2 (trypsin-like) subunits In preclinical studies using xenograft and genetically-engineered models of hematologic malignancies MLN2238 exhibited potent antitumor activity promoting apoptosis and suppressing pathways such as NF- B MLN2238 has research applications in oncology particularly against multiple myeloma and lymphoma including in bortezomib-resistant cell lines
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Medchemexpress LLC IGF-I/IGF-1 Human 5ug
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The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin As a potential physiological regulator it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin IGF-I/IGF-1 Protein Human (HEK293 hFc) is the recombinant human-derived IGF-I/IGF-1 protein expressed by HEK293 with N-hFc labeled tag
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Medchemexpress LLC Ponatinib (AP24534) | 943319-70-8 | 99.7% | 5MG
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Ponatinib (AP24534) | 943319-70-8 | 99.7% | 5MG
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Apexbio Technology LLC Xylose 25990-60-7 10mM (in 1mL DMSO)
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Xylose is a five-carbon monosaccharide widely utilized in biomedical and biochemical research Xylose serves as a metabolic precursor and signaling component in studies of carbohydrate metabolism It is commonly employed in vitro to investigate cellular uptake mechanisms intracellular sugar metabolic pathways and regulation of gene expression mediated by carbohydrate-inducible promoters Experimentally xylose supports the development and analysis of sugar-inducible expression systems microbial metabolic engineering optimization of cell culture medium formulations and exploration of glycosylation pathways Additionally xylose is used as a substrate for metabolic flux analyses and carbohydrate metabolism research in microbial systems
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Medchemexpress LLC Eprenetapopt | 5291-32-7 | 99.5% | 199.25 | 50 MG
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Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. It triggers apoptosis in tumor cells and also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance. Eprenetapopt acts as a p53 activator and TrxR1 inhibitor.
- Restores wild-type p53 functions in TP53-mutant cells.
- Triggers apoptosis in tumor cells.
- Targets selenoprotein thioredoxin reductase 1 (TrxR1).
- Acts as a p53 activator.
- Acts as a TrxR1 inhibitor.
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Medchemexpress LLC Cronidipine | 113759-50-5 | 98.8% | 598.04 | 1 MG
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Cronidipine is a calcium channel blocker used in cardiovascular disease related research. It is a potent vasoselective calcium channel blocker with a slow onset of action. This product is intended for research use only and is not sold to patients.
- Inhibits calcium channels.
- Supports cardiovascular disease research.
- Acts as a vasoselective agent.
- Exhibits a slow onset of action.
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Apexbio Technology LLC ω-Conotoxin GVIA 1mg
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-Conotoxin GVIA (CAS 106375-28-4) is a peptide neurotoxin derived from marine cone snails It acts as a highly selective blocker of N-type voltage-gated calcium channels (Cav2 2) on neuronal membranes inhibiting calcium influx and consequently reducing presynaptic neurotransmitter release Owing to its specificity for Cav2 2 channels -Conotoxin GVIA is frequently employed in neuroscience research to investigate mechanisms of synaptic transmission pain pathway signaling and neural circuit modulation Its use facilitates the analysis of presynaptic function and the development of models for studying pain and neuropharmacological processes
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Apexbio Technology LLC Kifunensine(Synonyms: Kif, Kifu, Kifunensin, KY-12420, Mannosidase inhibitor Kifunensine), 50mg, CAS: 109944-15-2.
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Kifunensine (CAS 109944-15-2) is a selective inhibitor of class I -mannosidases enzymes critical for glycoprotein processing and folding It primarily inhibits human endoplasmic reticulum -1 2-mannosidase I and Golgi -mannosidases IA IB and IC with Ki values of approximately 130 nM and 23 nM respectively Additionally it suppresses plant-derived -1 2-mannosidase I at IC50 values between 20 50 nM By blocking -mannosidase I activity in the endoplasmic reticulum (ER) kifunensine prevents the ER-associated degradation of misfolded glycoproteins thus serving as an investigative tool in studies of protein quality control pathways and glycoprotein biosynthesis
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Medchemexpress LLC Neridronate | 79778-41-9 | 98.0% | 5MG
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Neridronate | 79778-41-9 | 98.0% | 5MG
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Medchemexpress LLC 4-(1-phenylethyl)resorcinol | 85-27-8 | 99.4% | 214.26 g·mol⁻1 | C14H14O2 | 5G
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4-(1-Phenylethyl)resorcinol is a research-grade phenolic compound used as a potent skin-lightening active and biochemical reagent. It inhibits melanin synthesis and is used in formulation and analytical research to evaluate hyperpigmentation treatments and cosmetic efficacy. Supplied as a high-purity solid suitable for weighing, HPLC analysis, and formulation work.
- High purity suitable for research applications.
- Proven inhibition of melanin production for skin-lightening studies.
- Solid powder form for easy weighing and formulation.
- Available in multiple packaging sizes for small to larger scale studies.
- Accompanied by datasheet, certificate of analysis, and safety data sheet for quality and safety information.
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